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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
EZH2 p.Y646N Reference Standard
CBP10275
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Format | Genomic DNA |
Description | EZH2 Y646N (also reported as Y641N) lies within a SET domain of the Ezh2 protein (UniProt.org). Y646N confers a gain of function to the Ezh2 protein, as demonstrated by increased trimethylation at H3K27 (PMID: 22194861) and promotion of tumor growth in cell line derived xenograft models (PMID: 25493630). |
Technical Data | |
DNA Change | c.1936T>A |
AA Change | p.Y646N |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 50.00% |
Transcript | ENST00000320356 |
Cosmic ID | COSM37031 |
Chr position(GRCh37) | chr7:148508728 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | ![]() |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |

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