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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
EZH2 p.Y646S Reference Standard
CBP10277
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Format | Genomic DNA |
Description | EZH2 Y646S (corresponds to Y641S in the canonical isoform) lies within a SET domain of the Ezh2 protein (UniProt.org). Y646S confers a gain of function to the Ezh2 protein, as demonstrated by altered substrate specificity, increased catalytic efficiency for H3K27 trimethylation (PMID: 21190999), and is transforming in cell culture (PMID: 25493630). |
Technical Data | |
DNA Change | c.1937A>C |
AA Change | p.Y646S |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 33.33% |
Transcript | ENST00000320356 |
Cosmic ID | COSM37029 |
Chr position(GRCh37) | chr7:148508727 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | ![]() |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |

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