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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
KRAS p.A146T Reference Standard
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CBP10304
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| Format | Genomic DNA |
| Description | KRAS A146T is an exon four mutation that does not lie within any known functional domains of the Kras protein (UniProt.org). A146T decreases Kras GTPase activity, increases phosphorylation of Mek and Erk, and is transforming in cell culture and xenografts (PMID: 19075190, PMID: 20570890). |
| Technical Data | |
| DNA Change | c.436G>A |
| AA Change | p.A146T |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 88% |
| Transcript | NM_033360.4 |
| Cosmic ID | COSM19404 |
| Chr position(GRCh37) | chr12:25378562 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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