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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
AI-Edigene® KRAS p.G12D Reference Standard Plus
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CBP10429
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| Format | Genomic DNA |
| Description | KRAS G12D is a hotspot mutation that lies within a GTP binding region of the Kras protein (UniProt.org). G12D results in decreased Kras GTPase activity and increased activation of downstream signaling, promotes tumor formation in mouse models (PMID: 16474405, PMID: 26037647, PMID: 22871572) and is transforming in cell culture (PMID: 29533785). |
| Technical Data | |
| DNA Change | c.35G>A |
| AA Change | p.G12D |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000311936 |
| Cosmic ID | COSM521 |
| Chr position(GRCh37) | chr12:25398284 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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