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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
AI-Edigene® ERBB2 p.P780_Y781insGSP Reference Standard Plus
CBP10472
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Gene | ERBB2 |
Description | ERBB2 (HER2) P780_Y781insGSP (also referred to as G778_P780dup) results in the insertion of three amino acids in the protein kinase domain of the Erbb2 (Her2) protein between amino acids 780 and 781 (UniProt.org). P780_Y781insGSP results in constitutive activation of Erbb2 (Her2), increased downstream signaling, and is transforming in cell culture (PMID: 23220880, PMID: 28363995, PMID: 29967253). |
Technical Data | |
DNA Change | c.2330_2331insGGGCTCCCC |
AA Change | p.P780_Y781insGSP |
Mutation type | Insertion - In frame |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Copy Number | 2 |
Ploidy | 2.13 |
Transcript | NM_004448.3 |
Cosmic ID | N/A |
Chr position(GRCh37) | chr17:37881001_37881002 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | ![]() |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |

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