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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
AI-Edigene® NRAS p.G12V Reference Standard Plus
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CBP10523
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| Format | Genomic DNA |
| Description | NRAS G12V is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12V confers a loss of function on Nras protein as indicated by accumulation of GTP-bound Nras, loss of GTPase-activating protein sensitivity, leading to increased downstream pathway activation in cell culture (PMID: 19966803). |
| Technical Data | |
| DNA Change: | c.35G>T |
| AA Change | p.G12V |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | NM_002524.5 |
| Cosmic ID | COSM566 |
| Chr position(GRCh37) | chr1:115258747 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purity | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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