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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
TP53 p.G389W Reference Standard
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CBP10529
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| Format | Genomic DNA |
| Description | TP53, tumor protein p53, is a tumor suppressor (PMID: 30562755) and oncogene (PMID: 30577483) involved in cell cycle arrest and apoptosis, and is the most frequently mutated gene in cancer (PMID: 10065147, PMID: 22713868). TP53 germline mutations are common in Li-Fraumeni syndrome (PMID: 30239254) and somatic missense mutations are frequent in almost all cancer types (PMID: 30224644) and are also implicated in chemoresistance (PMID: 9927204, PMID: 24065105, PMID: 27066457). |
| Technical Data | |
| DNA Change | c.1165G>T |
| AA Change | p.G389W |
| Mutation type | Missense_Mutation |
| Zygosity | Heterozygous |
| Allelic Frequency | 50% |
| Transcript | ENST00000269305.4 |
| Cosmic ID | N/A |
| Chr position(GRCh37) | chr17:7572944 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4°C |
| Expiry | 36 months from the date of manufacture |
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