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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
TP53 p.P152L Reference Standard
| CBP10532 | |
| Format | Genomic DNA |
| Description | TP53, tumor protein p53, is a tumor suppressor (PMID: 30562755) and oncogene (PMID: 30577483) involved in cell cycle arrest and apoptosis, and is the most frequently mutated gene in cancer (PMID: 10065147, PMID: 22713868). TP53 germline mutations are common in Li-Fraumeni syndrome (PMID: 30239254) and somatic missense mutations are frequent in almost all cancer types (PMID: 30224644) and are also implicated in chemoresistance (PMID: 9927204, PMID: 24065105, PMID: 27066457). |
| Technical Data | |
| DNA Change | c.455C>T |
| AA Change | p.P152L |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100.00% |
| Transcript | ENST00000269305.4 |
| Cosmic ID | COSM10790 |
| Chr position(GRCh37) | chr17:7578475 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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