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RANK Effector Reporter Cell

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产品编号
CBP74125
货号:
CBP74125
品牌:
Cobioer
规格:
T-25 Flask
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CBP74125
I. Background
RANK/RANKL/OPG pathway plays a significant role in osteoclast maturation, which are the major cells in charge of bone resorption. If RANKL binds to the receptor RANK instead of binding to its decoy receptor Osteoprotegerin (OPG), it activates the NF-κB pathway to promote osteoclast survival and proliferation, resulting in the resorption of bone. Therefore, abnormal production of RANKL or OPG can cause osteoporosis and other bone-related disorders, making the RANKL/RANK signaling pathway a valuable target for drug development.
 
II. Introduction
Expressed gene: RANK
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: MEM+10%FBS+NEAA+NaP+200ug/ml hygromycin+1ug/ml puromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
III. Representative Data

Figure 1. Dose response of Human Recombinant RANKL in RANK Effector Reporter Cell Line (C31).

Figure 2. lnhibition of RANKL-induced Reporter Activity by RANKL Neutralizing Antibody in RANK Effector Reporter Cells (Clone31).

 
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  • RANK Effector Reporter Cell CBP74125说明书.pdf

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    2024-04-02
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