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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
BCR-ABL1 [E255K]/BaF3
CBP73318 | |
I. Introduction | |
Cell Line Name: |
BCR-ABL1 [E255K]/BaF3 |
Host Cell: |
Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: |
Anti-proliferation assay and PD assay |
Freeze Medium: |
90% FBS+10% DMSO |
Complete Culture Medium: |
RPMI-1640+10%FBS |
Mycoplasma Status: |
Negative |
II.Background | |
Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia chromosome. In rare CML cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene, which sometimes involve multiple chromosomes. |
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III. Representative Data | |
1.WB of BCR-ABL1 [E255K]/BaF3 |
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2.Sanger of BCR-ABL1 [E255K]/BaF3
Figure 2. BCR-ABL1 [E255K]/BaF3
Figure 3. BCR-ABL1 [E255K]/BaF3 Fusion |
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3. Anti-proliferation assay
Figure 4. CTG Proliferation Assay of BaF3 BCR-ABL1 E255K Cells (C3). |
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