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科研细胞

科研细胞

药靶细胞

药靶细胞

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NGS靶向捕获探针

NGS靶向捕获探针
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Claudin18.2/AGS

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产品编号
CBP74131
货号:
CBP74131
品牌:
Cobioer
规格:
T-25 Flask
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CBP74131
I. Background

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

 
II. Introduction
Host Cell:

AGS

Expressed gene:

Claudin18.2

Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium:

RPMI-1640+10%FBS+2ug/ml puromycin

Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Binding Assay,FACS
 
III. Description of Host Cell Line
Species: Homo sapiens, human
Tissue: Stomach
Disease: Gastric adenocarcinoma
Morphology: Epitheloid
Growth Properties: Adherent
 
IV. Representative Data

1. Claudin18.2/AGS


 

 

 

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