ADORA1 is a receptor for adenosine. It is demonstrated that the ADORA1 receptor is ubiquitous throughout the entire body. Activation of ADORA1 elicits an inhibition of adenylate cyclase and therefore a decrease in the cAMP concentration. ADORA1 receptors are implicated in sleep promotion by inhibiting wake promoting cholinergic neurons in the basal forebrain. Adenosine antagonists are widely used in neonatal medicine.
|Stability:||20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)|
|Freeze Medium:||90% FBS+10% DMSO|
|Culture Medium:||F12k+10%FBS+5ug/ml puromycin|
|Storage:||Liquid nitrogen immediately upon delivery|
Functional assay for A1 receptor
|Ⅲ. Description of Host Cell Line|
|Ⅳ. Representative Data|
Figure 1. NECA efffect on CHO-K1-ADORA1 clone 5.