南京科佰生物科技有限公司官方网站欢迎您的光临！
免费咨询热线： 4008-750-250
科研细胞
药靶细胞
标准品
NGS靶向捕获探针
Claudin18.2/NCI-N87
| CBP74148 | |
| I. Background | |
|
Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells. |
|
| II. Introduction | |
| Host Cell: | NCI-N87 |
| Expressed gene: |
Claudin18.2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| III. Description of Host Cell Line | |
| Species: | Homo sapiens, human |
| Tissue: | Stomach; derived from metastatic site: liver |
| Disease: | Gastric carcinoma |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| IV. Representative Data | |
|
1. Claudin18.2/NCI-N87
|
|
扫一扫，关注我们公众号
Copyright ©2021 www.cobioer.com All Rights Reserved. 南京科佰生物科技有限公司版权所有 苏ICP备13038923号