南京科佰生物科技有限公司官方网站欢迎您的光临!

免费咨询热线: 4008-750-250

搜索
确认
取消

科研细胞

科研细胞

药靶细胞

药靶细胞

标准品

标准品

NGS靶向捕获探针

NGS靶向捕获探针
浏览量:
1000

PD-L1/CD80&CD86 aAPC Cell

所属分类
返回列表
1
零售价
0.0
市场价
0.0
浏览量:
1000
产品编号
CBP74151
货号:
CBP74151
品牌:
Cobioer
规格:
T-25 Flask
物种:
组织:
数量
-
+
库存:
0
产品描述
参数
产品数据库
CBP74151
I. Background

The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.

B7-1, also known as CD80, is a membrane receptor found in activated antigen presenting cells (APC). 

B7-2 (CD86) signaling through CTLA4 (CD152) has been shown to inhibit T- cell activation. This co-inhibitory pathway can be overactive in many tumors, enabling cancers to escape the host’s immune system. CTLA4-blocking antibodies, including Ipilimumab (Yervoy) and Tremelimumab, have shown clinical efficacy in treating cancer.

 
II. Introduction
Expressed gene: PD-1、CD80、CD86
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+10%FBS+1ug/ml puromycin+800ug/ml hygromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
III. Representative Data

Figure 1. Dose Response of Blocking Antibodies in PD-1/CTLA4 Dual Effector Reporter Cells (C16) With PD-L1/CD80&CD86 aAPC Cells.

 

 

未找到相应参数组,请于后台属性模板中添加

相关文件

  • Manual download:CBP74151 PD-L1 CD80 CD86 aAPC Cell.pdf

    大小:
    2022-08-01
上一页
1

相关产品推荐

暂时没有内容信息显示
请先在网站后台添加数据记录。

联系我们

地址:南京市雨花台区长虹路222号/实验室地址:上海市浦东新区广丹路222号 

邮箱: sales@cobioer.com (销售部) tech@cobioer.com (技术部)

 COBIOER

扫一扫,关注我们公众号

Copyright ©2021 www.cobioer.com All Rights Reserved. 南京科佰生物科技有限公司版权所有 苏ICP备13038923号