EML4-ALK V1 [I1171S]/BaF3
|Cell Line Name：||EML4-ALK V1 [I1171S]/BaF3|
|Stability:||16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)|
|Application:||Anti-proliferation assay and PD assay|
|Freeze Medium:||90% FBS+10% DMSO|
|Complete Culture Medium:||RPMI-1640+10%FBS|
EML4-ALK results from the fusion of EML4 and ALK, resulting in constitutive kinase activity, transformation in cultured cells, and tumor activity in mouse models (PMID: 19064915, PMID: 17625570). EML4-ALK fusions have been associated with non-small cell lung cancer (PMID: 26755435).
|III. Representative Data|
1.WB of EML4-ALK V1 [I1171S]/BaF3
2. Sanger of EML4-ALK V1 [I1171S]/BaF3
Figure 1. EML4-ALK V1 [I1171S]/BaF3 Fusion
Figure 2. EML4-ALK V1 [I1171S]/BaF3 I1171S
3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 EML4-ALK V1 [l1171S] (C1).