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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
KRAS G12C-A59S/BaF3
| CBP73373 | |
| I. Introduction | |
| Cell Line Name： | KRAS G12C-A59S/BaF3 |
| Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
| Mycoplasma Status: | Negative |
| II.Background | |
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KRAS, KRAS proto-oncogene, GTPase, is a member of the small GTPase superfamily and a key regulator of the MAPK, PI3K/AKT/mTOR pathways (PMID: 23622131). KRAS mutations are identified in a wide range of cancers (PMID: 28666118). |
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| III. Representative Data | |
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1.Sanger of KRAS G12C-A59S/BaF3
Figure 1. KRAS(NM_033360.4):c.34G>T p.G12C
Figure 2. KRAS(NM_004985.5):c.175G>T p.A59S |
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2. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of KRAS G12C/A59S BaF3 Cells (C1). |
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