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NGF/hTRKA Effector Reporter Cell

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NGF/hTRKA Effector Reporter Cell

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产品编号
CBP74174
货号:
CBP74174
品牌:
Cobioer
规格:
T-25 Flask
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CBP74174
I. Background

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3. TrkA gene expression is under positive feedback from NGF signaling, and this pathway most likely is disrupted in AD by diminished retrograde transport of cortical NGF to CBF consumer neurons.

 
II.Introduction
Expressed gene: NGF、TRKA
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s): nerve growth factor (beta polypeptide), NGFB
Freeze Medium: 90% FBS+10%DMSO
Culture Medium: DMEM+10%FBS+2ug/ml puromycin+200ug/ml hrgromycin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
 
III. Representative Data

Figure 1. Recombinant NGF/hTRKA Effector Reporter Cell constitutively expressing NGF/hTRKA.

Figure 2.Dose Response of Recombinant Human NGF in NGF/TRKA Effector Reporter Cells(Clone21).

Figure 3.Inhibition of hNGF-induced Reporter Activity By TRKA Inhibitor in NGF/hTRKA Effector Reporter Cells(Clone 21).

Figure 4.Inhibition of hNGF-induced Reporter Activity By NGF Neutralization Ab in NGF/hTRKA Effector Reporter Cells(Clone 21).

 
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  • NGFhTRKA Effector Reporter Cell CBP74174说明书.pdf

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    2024-04-02
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