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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
HVEM/U2OS Cell
| CBP74178 | |
| I. Background | |
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HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry. |
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| II. Introduction | |
| Expressed gene: | HVEM |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | Mccoy's5A+10%FBS+2ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
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Figure 1. Recombinant HVEM/U2OS Cell constitutively expressing HVEM. |
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Figure 2. Inhibtion of HVEM Induced SHP2 Recruitment In BTLA/SHP2 Reporter Cells (C11) By Samples With HVEM/U2OS Cells (C7). |
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