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科研细胞
药靶细胞
标准品
NGS靶向捕获探针
528 Gene PLus TMB Panel
| 528 Gene Plus TMB Panel | ||||||||
| Cat No. | CBPF0003 | |||||||
| Descripition | 此实体瘤泛癌种Panel包含下列528个基因的全部编码区，30个常见实体瘤的融合基因热点内含子区域，99个微卫星不稳定检测位点，覆盖基因组约1.37Mb区域，支持包括碱基替换、插入、缺失检测分析。 | |||||||
| 528个基因：含全部外显子区域 | ||||||||
| ABL1 | IKBKE | STK11 | GATA2 | RPS6KA4 | ERCC1 | POLD1 | CREBBP | NOTCH2 |
| CBL | MERTK | ALOX12B | INSR | TCF3 | GNAS | RYBP | ETV1 | PRDM14 |
| DUSP4 | PDGFRB | CD70 | MSH3 | ARID2 | KDM5A | TMEM127 | HDAC1 | SETD2 |
| FH | RASA1 | ELOC | PIK3CB | CDK8 | MYD88 | AXIN1 | KMT2A | TRAF7 |
| IFNGR1 | STAG2 | FUBP1 | RICTOR | EPHB4 | PMAIP1 | CHEK1 | NFKBIA | BCL2 |
| MDM4 | AKT1 | INHBA | SYK | GLI1 | RRAS2 | ERF | PPP2R2A | CSF3R |
| PBRM1 | CCNQ | MLH1 | ARAF | JAK1 | TET2 | GSK3B | SDHD | FAM46C |
| RAD52 | EIF1AX | PIK3C2B | CDH1 | MUTYH | ATR | KEL | TP53 | HIST1H3B |
| SPOP | FOXA1 | REL | EPHA3 | PIK3R3 | CDKN2C | NEGR1 | BAP1 | KNSTRN |
| ABRAXAS1 | IKZF1 | STK19 | GATA3 | RPS6KB2 | ERCC2 | POLE | CRKL | NOTCH3 |
| CCND1 | MET | AMER1 | IRF2 | TCF7L2 | GPS2 | SDHA | ETV6 | PREX2 |
| E2F3 | PDK1 | CD79A | MSH6 | ARID5B | KDM5C | TMPRSS2 | HGF | SF3B1 |
| FLCN | RB1 | EMSY | PIK3CD | CDKN1A | MYOD1 | AXIN2 | KMT2B | TSC1 |
| IGF1 | STAT3 | FYN | RIT1 | ERBB2 | PMS1 | CHEK2 | NKX2-1 | BCL2L1 |
| MED12 | AKT2 | INPP4A | TAP1 | GNA11 | RTEL1 | ERG | PPP4R2 | CTCF |
| PDCD1 | CD22 | MPL | ARFRP1 | JAK2 | TGFBR1 | H3F3A | SESN1 | FANCA |
| RAD54L | EIF4A2 | PIK3C2G | CDK12 | MYC | ATRX | KIT | TP53BP1 | HIST1H3C |
| SPRED1 | FOXL2 | RET | EPHA5 | PIM1 | CEBPA | NF1 | BARD1 | KRAS |
| ACVR1 | IL10 | STK40 | GATA4 | RPTOR | ERCC3 | PPARG | CRLF2 | NOTCH4 |
| CCND2 | MGA | ANKRD11 | IRF4 | TEK | GREM1 | SDHAF2 | EZH1 | PRKAR1A |
| EED | PDPK1 | CD79B | MST1R | ASXL1 | KDM6A | TNFAIP3 | HIST1H1C | SGK1 |
| FLT1 | RBM10 | EP300 | PIK3CG | CDKN1B | NBN | AXL | KMT2C | TSC2 |
| IGF1R | STAT5A | GABRA6 | RNF43 | ERBB3 | PMS2 | CIC | NKX3-1 | BCL2L11 |
| MEF2B | AKT3 | INPP4B | TAP2 | GNA13 | RUNX1 | ERRFI1 | PPP6C | CTLA4 |
| PDCD1LG2 | CD274 | MRE11 | ARID1A | JAK3 | TGFBR2 | H3F3B | SESN2 | FANCC |
| RAF1 | EIF4E | PIK3C3 | CDK4 | MYCL | AURKA | KLF4 | TP63 | HIST1H3D |
| SRC | FOXO1 | RHEB | EPHA7 | PLCG2 | CENPA | NF2 | BBC3 | LATS1 |
| ACVR1B | IL7R | SUFU | GATA6 | RRAGC | ERCC4 | PPM1D | CSDE1 | NPM1 |
| CCND3 | MITF | APC | IRS1 | TERT | GRIN2A | SDHB | EZH2 | PRKCI |
| EGFL7 | PGR | CDC42 | MTAP | ASXL2 | KDR | TNFRSF14 | HIST1H2BD | SH2B3 |
| FLT3 | RECQL | EPAS1 | PIK3R1 | CDKN2A | NCOA3 | B2M | KMT2D | TSHR |
| IGF2 | STAT5B | GATA1 | ROS1 | ERBB4 | PNRC1 | COP1 | NOTCH1 | BCL2L2 |
| MEN1 | ALK | INPPL1 | TBX3 | GNAQ | RXRA | ESR1 | PRDM1 | CTNNA1 |
| PDGFRA | CD276 | MSH2 | ARID1B | JUN | TIPARP | H3F3C | SESN3 | FANCD2 |
| RARA | ELF3 | PIK3CA | CDK6 | MYCN | AURKB | KLHL6 | TRAF2 | HIST1H3E |
| SRSF2 | FOXP1 | RHOA | EPHB1 | PLK2 | CHD4 | NFE2L2 | BCL10 | LATS2 |
| AGO2 | INHA | SUZ12 | GID4 | RRAS | ERCC5 | PPP2R1A | CSF1R | NRAS |
| CCNE1 | MKNK1 | AR | IRS2 | TET1 | GRM3 | SDHC | EZR | PRKD1 |
| EGFR | PHOX2B | CDC73 | MTOR | ATM | KEAP1 | TOP1 | HIST1H3A | SH2D1A |
| FLT4 | RECQL4 | EPCAM | PIK3R2 | CDKN2B | NCOR1 | BABAM1 | KMT5A | TYRO3 |
| BCL6 | CUL4A | FAS | HIST2H3D | MAP2K4 | P2RY8 | RAC2 | SOX10 | CASP8 |
| CTNNB1 | FANCG | HIST1H3J | MAP2K1 | NUF2 | RAB35 | SOCS1 | ZNF217 | DOT1L |
| FANCE | HIST1H3H | MAF | NTRK2 | PTPRT | SMYD3 | YES1 | CARD11 | FGFR3 |
| HIST1H3F | LTK | NTHL1 | PTPRO | SMARCD1 | XRCC2 | BTK | DNMT3A | IDH1 |
| LMO1 | NSD3 | PTPN11 | SMARCA4 | XIAP | BTG1 | DNAJB1 | FGFR1 | MDC1 |
| NSD1 | PTEN | SMAD3 | WT1 | BRD4 | DICER1 | FGF4 | ICOSLG | PARP3 |
| PRKN | SLX4 | VTCN1 | BRCA1 | DDR1 | FGF23 | HSD3B1 | MAX | RAD51C |
| SHOC2 | VEGFA | BMPR1A | DAXX | FGF14 | HOXB13 | MAPK3 | PARP1 | SOX9 |
| U2AF1 | BIRC3 | CYP17A1 | FGF10 | HLA-B | MAP3K14 | PAK5 | RAD51 | CBFB |
| BCOR | CXCR4 | FAT1 | HIST3H3 | MAP3K1 | PAK1 | RAD21 | SOX17 | DROSHA |
| CUL3 | FANCL | HIST2H3C | MAP2K2 | NUP93 | RAC1 | SOS1 | ZNF703 | FGFR4 |
| FANCF | HIST1H3I | MALT1 | NTRK3 | QKI | SNCAIP | ZFHX3 | CARM1 | IDH2 |
| HIST1H3G | LYN | NTRK1 | PTPRS | SMO | YAP1 | CALR | DNMT3B | MDM2 |
| LRP1B | NT5C2 | PTPRD | SMARCB1 | XPO1 | BTG2 | DNMT1 | FGFR2 | PAX5 |
| NSD2 | PTP4A1 | SMAD4 | WWTR1 | BRIP1 | DIS3 | FGF6 | ID3 | RAD51D |
| PTCH1 | SMAD2 | WISP3 | BRCA2 | DDR2 | FGF3 | HSP90AA1 | MCL1 | SPEN |
| SHQ1 | VHL | BRAF | DCUN1D1 | FGF19 | HRAS | MAPKAP1 | PARP2 | |
| UPF1 | BLM | CYSLTR2 | FGF12 | HNF1A | MAPK1 | PALB2 | RAD51B | |
| BCORL1 | CYLD | FBXW7 | HLA-A | MAP3K13 | PAK3 | RAD50 | SOX2 | |
| 30个融合基因区域：部分内含子区域 | ||||||||
| 基因 | 区域 | 基因 | 区域 | |||||
| ALK | intron:17;18;19;20;21 | KMT2A | intron:6;7;8;9;10;11 | |||||
| BCR | intron:8;13;14 | MET | intron:14 | |||||
| BRAF | intron:7;8;9;10 | MYC | intron:1 | |||||
| BRCA1 | intron:2;7;8;12;16;19;20 | NOTCH2 | intron:26 | |||||
| BRCA2 | intron:2 | NTRK1 | intron:6;7;8;9 | |||||
| CD74 | UTR;intron:6;7;8 | NTRK2 | intron:12;15 | |||||
| ETV4 | intron:5;6 | NUTM1 | intron:1 | |||||
| ETV5 | intron:6;7 | PDGFRA | intron:7;9;11 | |||||
| ETV6 | intron:5;6 | RAF1 | intron:4;5;6;7;8;9 | |||||
| EWSR1 | intron:6;7;8;9;10;11;12;13 | RARA | intron: | |||||
| EZR | intron:10;11;12 | RET | intron:6;7;8;9;10;11 | |||||
| FGFR1 | intron:1;5 | ROS1 | intron:32;33;34;35 | |||||
| FGFR2 | intron:1;17 | SDC4 | intron:2 | |||||
| FGFR3 | intron14;16;17 | SLC34A2 | intron:4 | |||||
| KIT | intron:16 | TMPRSS2 | intron:1;2;3 | |||||
| 99个微卫星不稳定位点 | ||||||||
| BAT26 | 2B3D NCI Panel(CSCO指南);Promega Panel | |||||||
| BAT25 | 2B3D NCI Panel(CSCO指南);Promega Panel | |||||||
| D5S346 | 2B3D NCI Panel(CSCO指南) | |||||||
| D2S123 | 2B3D NCI Panel(CSCO指南) | |||||||
| D17S250 | 2B3D NCI Panel(CSCO指南) | |||||||
| NR21 | Promega Panel | |||||||
| NR24 | Promega Panel | |||||||
| NR27 | Promega Panel | |||||||
| MONO27 | Promega Panel | |||||||
| MSI:10-99 | 额外已验证的89个微卫星位点 | |||||||
| Product Information | ||||||||
| Intended Use | Research Use Only | |||||||
| Unit Size | 96 rxn | |||||||
| Storage | -20°C | |||||||
| Expiry | 12 months from the date of manufacture | |||||||
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