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科研细胞

科研细胞

药靶细胞

药靶细胞

标准品

标准品

NGS靶向捕获探针

NGS靶向捕获探针
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hERBB3/CHO

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产品编号
CBP75069
货号:
CBP75069
品牌:
Cobioer
规格:
T-25 Flask
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CBP75069
I. Background
ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
 
II. Introduction
Host Cell: CHO
Expressed gene: hERBB3
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium:

F12K+10%FBS+5ug/ml blasticidin

Storage: Liquid nitrogen
 
III. Description of Host Cell Line
Organism: Hamster 
Tissue: Ovary
Disease: Hamster Chinese ovary
Morphology: Epithelial
Growth Properties: Adherent
 
IV. Representative Data
 
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