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NKP46 Effector Reporter Cell

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NKP46 Effector Reporter Cell

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产品编号
CBP74220
货号:
CBP74220
品牌:
Cobioer
规格:
T-25 Flask
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CBP74220
I. Background
NKp46 (also known as Natural cytotoxicity triggering receptor 1, or NCR1) is an important natural killer (NK) cell-activating receptor expressed on the surface of human NK cells, and it is involved in cytotoxicity. NKp46 participates in the activation of NK cells against pathogens, tumor cells, and virally infected cells. It also plays an important role in autoimmune conditions, including type I diabetes. NKp46 expression is often conserved on infiltrating NK cells in most solid tumors, and NKp46 is a diagnostic biomarker and possible therapeutic target for gastrointestinal T-cell lymphoproliferative diseases. Although a few infectious NKp46 ligands have been identified, endogenous NKp46 cell surface ligands are unknown. Recently, it was reported that NKp46 binds to externalized calreticulin (ecto-CRT), which translocate from the ER (endoplasmic reticulum) to the plasma membrane in situations of cellular stress such as chemotherapy and senescence. This leads to NK cell degranulation and target cell killing and can participate in controlling cancer. Further studies will elucidate the exact mechanism and roles of NKp46 and its ligands in disease and allow the development of new therapeutics for cancer therapy.
 
II. Introduction
Expressed gene: NKP46
Stability: 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: RPMI-1640+10%FBS+1ug/ml puromycin+800ug/ml hygromycin+5ug/ml blasticidin
Mycoplasma Testing: Negative
Storage: Liquid nitrogen
Application(s): Functional(Report Gene) Assay
 
III. Representative Data

Figure 1. Recombinant NKP46 Effector Reporter Cell stably expressing NKP46.

Figure 2. Dose Response of NKP46 Agonist Ab in NKP46 Effector Reporter Cells (C14).

 
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