hCD166/MC-38

CBPG0162

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产品描述

产品数据库

I. Background
CD166（也称为 ALCAM）是一种跨膜糖蛋白，属于免疫球蛋白超家族（IgSF）成员。其在多种肿瘤中高表达，包括结直肠癌、乳腺癌、前列腺癌和黑色素瘤；并在多种细胞类型中表达，包括上皮细胞、内皮细胞、神经元和免疫细胞。CD166 在细胞间相互作用、信号传导和细胞迁移中起重要作用，同时也与肿瘤的发生、发展和转移密切相关。CD166 通过其胞外区与其他细胞表面分子（如 CD166 或 CD6）结合，介导细胞间粘附；还可以通过激活下游信号通路（如 PI3K/AKT 或 MAPK 通路）调节细胞增殖、存活和迁移。

II. Introduction
Host Cell:	MC-38
Expressed gene:	hCD166
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	DMEM+10%FBS+2 μg/ml Puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen

III. Description of Host Cell Line
Organism:	Mus musculus, mouse
Tissue:	Colon
Morphology:	Epitheloid cell
Growth Properties:	Adherent

IV. Representative Data
Figure 1. Recombinant hCD166/MC-38 stably expressing hCD166.

V. In VIVO Data

Index	Content
Animal	C57BL/6J, 7weeks, female
Implanted Position	Subcutaneous (right flank region)
Injected Cell Numbers	1×10^6/0.1ml
Matrix gel	Without matrix gel

1. Weight Change

Figure 2. hCD166/MC38 Mean Body Weight ± SEM.

2. Tumor Volume

Figure 3. hCD166/MC38 Mean Tumor Volume ± SEM.

NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).