hCDCP1/MC-38
CBPG0213
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| I. Background | |
| CDCP1（CUB 结构域包含蛋白 1）是一种跨膜糖蛋白，编码基因位于人类染色体 3p21.3，其编码的蛋白由 836 个氨基酸组成，包含三个胞外 CUB 结构域、跨膜区及胞内酪 氨酸激酶结合位点。该蛋白在细胞黏附、迁移及信号传导中发挥核心作用，并广泛参与肿 瘤发生发展及心血管疾病调控。 在肿瘤生物学中，CDCP1 呈现高度表达特性，尤其在前列腺癌、结直肠癌、肺癌、胰 腺癌及乳腺癌等恶性疾病中显著。其通过激活 PI3K/Akt、MAPK/ERK 等信号通路，促进肿 瘤细胞增殖、侵袭及转移。除肿瘤领域外，CDCP1 基因变异近期被发现与心力衰竭相关， 其可能通过调节心脏纤维化影响疾病进程，为心血管疾病治疗提供新靶点。综上，CDCP1 作为多信号通路交汇节点，在疾病发生发展中具有关键调控作用，其功能解析为肿瘤及心 血管疾病的精准诊疗开辟了新路径。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hCDCP1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 6weeks, female |
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Implanted Position |
Subcutaneous (right lower flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hCDCP1/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hCDCP1/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
