hVEGFA/MC-38
CBPG0239
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| I. Background | |
| VEGFA是血管内皮生长因子家族中最主要的成员，负责调控新生血管的形成。在多种实体瘤中，VEGFA往往过度表达，刺激大量新生血管长入肿瘤，为其提供氧气和营养，从而促进肿瘤的生长与扩散。临床上，贝伐珠单抗等抗血管生成药物通过抑制VEGFA的活性来切断肿瘤的血供，达到抑制肿瘤的效果。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | VEGFA |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 7weeks, female |
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Implanted Position |
Subcutaneous (right flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hVEGFA/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hVEGFA/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
