hAMHR2/MC-38
CBPG0259
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| I. Background | |
| AMHR2(抗苗勒管激素受体 2 型)是转化生长因子-β(TGF-β)超家族关键受体,位于染色体 12q13,由 11 个外显子编码 573 个氨基酸的跨膜蛋白,含胞外结合域、跨膜区及 胞内丝氨酸/苏氨酸激酶结构域。其核心功能是与抗苗勒管激素(AMH)结合,调控性别 分化:在男性胚胎期,AMH 由睾丸支持细胞分泌,结合 AMHR2 后激活 SMAD 信号通路,促使苗勒管退化,确保男性生殖系统正常发育;女性因缺乏 AMH,苗勒管发育为子宫、输卵管等。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | AMHR2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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