hDPP4/MC-38
CBPG0269
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| I. Background | |
| DPP4基因编码二肽基肽酶4，是一种多功能跨膜糖蛋白，也是免疫分子CD26。它的核心功能是通过酶活性快速降解胰高血糖素样肽-1（GLP-1）等肠促胰岛素，从而负向调控血糖，因此成为2型糖尿病治疗药物（如西格列汀）的重要靶点。同时，它在免疫系统中作为T细胞共刺激分子发挥作用，并且是中东呼吸综合征冠状病毒（MERS-CoV）入侵细胞的功能性受体，广泛参与血糖调节、免疫应答和病毒感染等多种生理病理过程。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hDPP4 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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