hLRRC15/MC-38

CBPG0108

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产品描述

产品数据库

I. Background
LRRC15（Leucine Rich Repeat Containing 15），富含 15 个亮氨酸的重复序列，是 LRRC 超家族的成员之一。LRRC15 同时能够正调控细胞的迁移，调控受体介导的病毒粒子与宿主细胞的附着，且蛋白质定位于细胞质膜。LRRC15 主要是以蛋白-蛋白和蛋白-基质相互作用方式，参与细胞-细胞和/或-细胞外基质的相互作用，参与炎性反应相关疾病，同时在细胞粘附、信号转导、DNA 修复等过程中有重要作用。LRRC15 在正常组织中的低表达，而在骨肉瘤、卵巢癌、乳腺癌、胰腺导管腺癌、促结缔组织增生型小圆细胞癌等癌症中高表达。

II. Introduction
Host Cell:	MC-38
Expressed gene:	hLRRC15
Stability:	32 passages
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	DMEM+10%FBS+5μg/ml Puromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen

III. Description of Host Cell Line
Organism:	Mouse
Tissue:	Colon
Morphology:	Epitheloid cell
Growth Properties:	Adherent

IV. Representative Data
Figure 1. Recombinant hLRRC15/MC-38 stably expressing hLRRC15.

V. In VIVO Data

Index	Content
Animal	C57BL/6J, 6weeks, female
Implanted Position	Subcutaneous (right lower flank region)
Injected Cell Numbers	1×10^6/0.1ml
Matrix gel	Without matrix gel

1. Weight Change

Figure 2. hLRRC15/MC38 Mean Body Weight ± SEM.

2. Tumor Volume

Figure 3. hLRRC15/MC38 Mean Tumor Volume ± SEM.

NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).