hSLC34A2(NPT2b)/MC-38
CBPG0248
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| I. Background | |
| SLC34A2 基因(solutecarrierfamily 34 member2)属于溶质转运蛋白家族 SLC34 的成员 之一,该家族包括 SLC34A1、SLC34A2 和 SLC34A3,分别编码 Na 依赖的 Pi 转运蛋白 NaPi-Ⅱa、NaPi-Ⅱb 和 NaPi-Ⅱc,三者氨基酸序列相近但分布部位不同,在维持体内无机磷 的平衡中都起着极其重要的作用。SLC34A2 在各种人体组织中表达,但在肺、小肠和肾脏 中的表达最高。SLC34A2 的作用是运输磷酸盐并维持磷酸盐平衡,磷酸盐通过调节细胞分 化和基因表达,在器官发育(如脑、肺) 和肿瘤发生过程中发挥关键作用。SLC34A2 突 变会导致肺泡微石症(PAM)、低磷血症、不孕症的发生,SLC34A2 与肿瘤发生和进展有 关,SLC34A2 在乳腺癌中低表达,在卵巢癌和甲状腺状癌中检测到 SLC34A2 过表达。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | SLC34A2(NPT2b) |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 7weeks, female |
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Implanted Position |
Subcutaneous (right flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change

Figure 2. hSLC34A2(NPT2b)/MC-38 Mean Body Weight ± SEM.
2. Tumor Volume

Figure 3. hSLC34A2(NPT2b)/MC-38 Mean Tumor Volume ± SEM.
NOTE:The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
