Mouse CCR9 CHO
CBP71612
询 价
索取protocol
产品描述
产品数据库
| I. Background | |
| 趋化因子受体 9 (chemokine receptor 9,CCR9),属于β趋化因子受体家族。它由转录本 A(369 个氨基酸,42 kDa)和 B(357 个氨基酸,40.8 kDa)组成。CCR9 主要分布在未成熟的 T 淋巴细胞和肠细胞表面,结合其特异性配体,在 T 淋巴细胞发育和组织特异 性归巢中发挥作用。研究证明,CCR9 在多种癌症中高表达,是一种潜在的肿瘤生物标志 物,可用于诊断和治疗。 CCR9 被其特异性配体 CCL25 激活后,可以与许多信号通路相互作用,特别是与肿瘤耐药和转移有关的信号通路。 | |
| II. Description | |
| Mouse CCR9 CHO 细胞药靶模型很好的模拟了 Mouse CCR9 的信号转导过程。 | |
| III. Introduction | |
| Expressed gene: |
Mouse CCR9 |
| Host Cell: |
CHO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Puromycin |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for Mouse CCR9 |
| Assay Format: | Gi |
| IV. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
V. Representative Data![]() Figure 1.Recombinant Mouse CCR9 CHO stably expressing Mouse CCR9. ![]() Figure 2. HTRF cAMP Assay with Mouse CCR9 CHO(C105). |
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