hEpCAM-Luc/ID8
CBPG0264
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| I. Background | |
| EpCAM（上皮细胞黏附分子，CD326）是一种I型跨膜糖蛋白，主要在上皮细胞中表达，参与细胞黏附、增殖、分化和信号转导。在多种上皮来源的肿瘤（如结直肠癌、乳腺癌、肝癌等）中常呈现高表达，因此被广泛用作循环肿瘤细胞（CTC）的检测标志物和肿瘤靶向治疗的潜在靶点。此外，EpCAM的胞内段可被γ-分泌酶切割后进入细胞核，调控与细胞周期及增殖相关基因的转录。 | |
| II. Introduction | |
| Host Cell: | ID8 |
| Expressed gene: | EpCAM-Luc |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2μg/ml Puromycin+5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mouse |
| Tissue: | Ovarian |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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Figure 1. Recombinant hEpCAM-Luc/ID8 stably expressing hEpCAM-Luc. |
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