Canine CTR&RAMP3 UM-UC-3
CBP71643
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产品数据库
| I. Background | |
| Canine CTR(犬降钙素受体)与RAMP3(受体活性修饰蛋白3)形成的复合物,是Amylin(胰淀素)受体AMY3的一种。CTR本身是一种B类G蛋白偶联受体,而RAMP3作为重要的辅助蛋白,能改变CTR的配体特异性并辅助其转运至细胞膜。与CTR/RAMP1复合物相比,犬CTR/RAMP3形成的AMY3受体对CGRP(降钙素基因相关肽)的亲和力相对较低,但在cAMP信号通路激活等功能上仍扮演重要角色。 | |
| II. Description | |
| Canine CTR&RAMP3 UM-UC-3 细胞药靶模型很好的模拟了体内 CTR&RAMP3 的信号转导过程。 | |
| III. Introduction | |
| Host Cell: |
UM-UC-3 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
MEM+10%FBS+1% NEAA+ 1mM NaP+2μg/ml Puromycin+5μg/ml Blasticidin
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| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for Canine CTR&RAMP3 |
| Transducer: | Gs |
| IV. Representative Data | |
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