APRIL CHO
CBP74557
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| I. Background | |
| APRIL(全称A Proliferation-Inducing Ligand,即增殖诱导配体,又名TNFSF13或CD256)是肿瘤坏死因子(TNF)超家族的第13号成员。 它的核心功能是调节B细胞存活与增殖。通过与受体BCMA和TACI结合,APRIL在免疫系统中支持浆细胞(负责分泌抗体的细胞)长期存活。 在病理上,高表达的APRIL与自身免疫病(如系统性红斑狼疮)及多发性骨髓瘤等B细胞相关癌症密切相关,是这些疾病治疗的重要潜在靶点。 | |
| II. Description | |
| APRIL CHO细胞,在 CHO-K1 细胞的基础上,稳定表达 APRIL 。 | |
| III. Introduction | |
| Expressed gene: | APRIL |
| Host Cell: | CHO-K1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
![]() Figure 1. Recombinant APRIL CHO constitutively expressing APRIL. |
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