IL10RA CHO
CBP74560
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| I. Background | |
| IL10RA(白细胞介素-10受体α亚基,又称CD210)是IL-10受体的特异性配体结合链,主要表达于免疫细胞表面。其核心功能是与辅助亚基IL10RB形成受体复合物,识别并结合抗炎细胞因子IL-10,通过激活JAK1/TYK2-STAT3信号通路抑制巨噬细胞和T细胞的炎症反应,在维持肠道免疫平衡中尤为关键。IL10RA基因缺陷是导致极早发性炎症性肠病的确切病因,具有常染色体隐性遗传特点,其基因多态性与白塞病等自身免疫病易感性相关。 | |
| II. Description | |
| IL10RA CHO细胞,在 CHO-K1 细胞的基础上,稳定表达 IL10RA 。 | |
| III. Introduction | |
| Expressed gene: | IL10RA |
| Host Cell: | CHO-K1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
![]() Figure 1. Recombinant IL10RA CHO constitutively expressing IL10RA. |
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