Cyno CTR COS7
CBP71648
询 价
索取protocol
产品描述
产品数据库
| I. Background | |
| Cyno CTR（食蟹猴降钙素受体，基因 CALCR） 是与人高度同源（>97%）的 B 类七次跨膜 GPCR，主要表达于破骨细胞、甲状腺 C 细胞及肾小管，结合降钙素（Calcitonin）激活 Gs/Gq→cAMP/Ca²⁺ 通路，抑制骨吸收、促进尿钙排泄以维持钙磷稳态。 | |
| II. Description | |
| Cyno CTR COS7 细胞药靶模型很好的模拟了体内 CTR 的信号转导过程。 | |
| III. Introduction | |
| Host Cell: |
COS7 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: |
DMEM+10%FBS+2μg/ml Puromycin
|
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for Cyno CTR |
| Transducer: | Gs |
| IV. Representative Data | |
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