STEAP1 22RV1
CBP74588
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| I. Background | |
| STEAP1（Six Transmembrane Epithelial Antigen of the Prostate 1，前列腺癌六次跨膜上皮抗原1）定位于人染色体 7q21.13，编码一种六次跨膜的细胞膜蛋白，主要表达于前列腺、膀胱等上皮组织及细胞间连接处。它在转移性去势抵抗性前列腺癌、尤文肉瘤等多种肿瘤中显著高表达，虽自身缺乏典型NADPH结合域，但可通过与STEAP2等形成异源三聚体参与铁/铜离子还原与稳态调控，并介导细胞间通讯与肿瘤进展，是目前ADC、双抗及CAR-T疗法的热门肿瘤膜靶点。 | |
| II. Description | |
| STEAP1 22RV1细胞，在 22RV1细胞的基础上，稳定表达 STEAP1 。 | |
| III. Introduction | |
| Expressed gene: | STEAP1 |
| Host Cell: | 22RV1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
 Figure 1. Recombinant STEAP1 22RV1 constitutively expressing STEAP1. |
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