Activin E/ALK7 Effector Reporter Cell
CBP74555
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| I. Background | |
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Activin E（由 INHBE 基因编码）与 ALK7（由 ACVR1C 基因编码）是 TGF-β 超家族中的一组配体-受体对。当 Activin E 与 ALK7 结合后，会激活 SMAD2/3 信号通路，从而强烈抑制脂肪细胞中的脂肪分解。该通路促进脂肪储存、抑制脂肪分解。因此，阻断 Activin E/ALK7 信号轴已成为治疗肥胖及相关代谢疾病的一个有前景的策略。 |
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| II. Description | |
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Activin E/ALK7 Effector Reporter Cell 报告基因药靶模型很好的模拟了体内 Activin E/ALK7 的信号转导过程。 |
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| III. Introduction | |
| Expressed gene: | Activin E/ALK7 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin+ 200 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 1. Recombinant Activin E/ALK7 Effector Reporter Cell stably expressing Activin E/ALK7.  Figure 2. Dose Response of Recombinant Human Activin E in Activin E/ALK7 Effector Reporter Cell( C34).  Figure 3. Inhibition of Human Activin E Induced Reporter Activity by ALK7 Blocking Ab in ActivinE/ALK7 Effector Reporter Cell( C34). |
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