EGFRVIII LN229
CBP73410
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| I. Background | |
| EGFRvIII是表皮生长因子受体（EGFR）最常见的胞外区突变体，由EGFR基因外显子2-7的框内缺失（共801个碱基）导致，造成胞外结构域267个氨基酸的删除。这种结构缺失使其无法与任何已知配体结合，却具有低水平的组成性酪氨酸激酶活性，且因内吞和降解受损而信号持续存在。 | |
| II. Description | |
| EGFRVIII LN229细胞，在 LN229细胞的基础上，稳定表达 EGFRVIII 。 | |
| III. Introduction | |
| Expressed gene: | EGFRVIII |
| Host Cell: | LN229 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
 Figure 1. Recombinant EGFRVIII LN229 constitutively expressing EGFRVIII. |
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